A Confederacy of Dunces is a tragicomic tale featuring the unforgettable Ignatius J. Reilly, a 30-year-old medievalist who lives with his mother in New Orleans. Ignatius' life of leisure is disrupted by a series of misadventures, beginning with a near-arrest and a car accident involving his inebriated mother. As Ignatius is thrust into the working world, he turns his employers at the Levy Pants Company upside down.

The narrative is populated by a cast of marvelous secondary characters, including a stripper with a talented cockatoo, a septuagenarian secretary, a gay blade, a sinister nightclub owner, and Myrna Minkoff, the girl Ignatius loves to loathe. Ignatius' journey is a modern-day quixotic quest against the forces of modernity and ignorance, making him a giant of comedic proportions in a world that seems too small to contain him.

Author John Kennedy Toole showcases a New Orleans that teems with life and energy, crafting a story that is as complex and vibrant as anything found in Dickens. Despite its comic surface, the novel reveals a deep melancholy beneath its hero's bluster, making Ignatius not just a figure of fun but a character with whom readers can sympathize.