Interview with the Vampire is the captivating story of Louis, narrating his own profound and complex journey through both mortal and immortal life. He shares his transformation into a vampire by the enigmatic Lestat, and his reluctant acceptance of the vampiric lifestyle. Louis's narrative takes us through the vibrant streets of New Orleans, marking pivotal moments such as his encounter with the tragically lost young Claudia, whom he turns into a vampire, thus damning her to eternal childhood with an adult's mind and desires.

Together, Louis and Claudia form a powerful bond and attempt to create a semblance of normalcy in the lavish French Quarter. However, their shared loathing for Lestat propels them on a quest for others like themselves across the globe. Their journey leads them to Paris and the Theatre des Vampires, where they meet Armand, who introduces them to a community of vampires. But this new society brings its own challenges and perils.

The novel, which originated as a short story, blossomed into a richly detailed chronicle of a tormented soul's experiences, as well as the political and social upheavals spanning two continents. It introduces the iconic character of Lestat, a complex figure who elicits both fascination and aversion. At its core, Interview with the Vampire delves into timeless themes of immortality, transformation, loss, desire, and power.