Demon Copperhead is set in the mountains of southern Appalachia, unraveling the life of a boy born to a teenage single mother in a single-wide trailer. He possesses no material wealth, save for his dead father's good looks, copper-colored hair, a sharp wit, and an innate ability to survive. Told through his candid perspective, Demon navigates the treacherous landscape of foster care, child labor, failing schools, athletic achievement, addiction, disastrous romances, and profound losses.

As he confronts the harsh reality of his own invisibility within a society that has relegated rural people to the shadows, even in popular culture where superheroes favor cities over the countryside, Demon's journey is a testament to resilience.

Inspired by Charles Dickens' David Copperfield, which itself was a product of Dickens' experiences with institutional poverty and its detrimental effects on children, Demon Copperhead carries forward Dickens' legacy of indignation and empathy. Barbara Kingsolver employs these sentiments to weave a narrative that is both a nod to a classic and a voice for the modern generation of 'lost boys' and all those rooted to places of cursed beauty they cannot fathom leaving.