Against Nature, also known as Against The Grain, is a wildly original fin-de-siècle novel that follows the journey of its sole character, Des Esseintes. He is a decadent, ailing aristocrat who retreats to an isolated villa where he indulges his taste for luxury and excess.

Veering between nervous excitability and debilitating ennui, he gluts his aesthetic appetites with classical literature and art, exotic jewels (with which he fatally encrusts the shell of his tortoise), rich perfumes, and a kaleidoscope of sensual experiences.

The novel is known as the original handbook of decadence and has enjoyed a cult readership from its publication to the present day.