Flesh and Blood takes readers on a masterful journey through four generations of the Stassos family, exploring the dynamics of a family striving to "come of age" in the 20th century.

In 1950, Constantine Stassos, a Greek immigrant laborer, marries Mary Cuccio, an Italian-American girl. Together, they have three children: Susan, an ambitious beauty; Billy, a brilliant homosexual; and Zoe, a wild child. Over the years, a web of tangled longings, love, inadequacies, and unfulfilled dreams unfolds as Mary and Constantine's marriage fails, and Susan, Billy, and Zoe leave to create families of their own.

Zoe raises a child with the help of a transvestite, Billy makes a life with another man, and Susan raises a son conceived in secret, each extending the meaning of family and love. With the power of a Greek tragedy, the story builds to a heartbreaking crescendo, offering a glimpse into contemporary life that will echo in one's heart for years to come.