Isserley picks up hitchhikers with big muscles. She, herself, is tiny—like a kid peering up over the steering wheel. She has a remarkable face and wears the thickest corrective lenses anyone has ever seen. Her posture suggests some spinal problem. Her breasts are perfect; perhaps implants. She is strangely erotic yet somehow grotesque, vulnerable yet threatening.

Her hitchhikers are a mixed bunch of men—trailer trash and traveling postgrads, thugs and philosophers. But Isserley is only interested in whether they have families and whether they have muscles. Then, it's only a question of how long she can endure her pain—physical and spiritual—and their conversation.

"Under the Skin" takes us on a heart-thumping ride through dangerous territory—our own moral instincts and the boundaries of compassion.