Dhimas and Ruben are two students pursuing their studies in the United States. Dhimas is attending George Washington University, while Ruben is at John Hopkins Medical School. They first meet at a vibrant party hosted by a student association in America. Initially, they engage in a conversation that pits them against each other due to their backgrounds: Dhimas hails from a wealthy family, whereas Ruben is a scholarship student.

After Ruben tries serotonin, they grow closer, discussing topics ranging from science and technology to Ruben's revelation of being gay. Unexpectedly, Dhimas also reveals he is gay, and they become a couple, despite living in separate apartments. They believe this distance keeps their relationship fresh and exciting.

During their meeting at the party, they pledge to create a masterpiece, a work or research that bridges various branches of science. This novel is not just a romance; it is a wide-ranging exploration that touches hearts and minds.