The Rosie Project is narrated by Don Tillman, a socially awkward genetics professor on an unusual quest: to find out if he is capable of true love. Don Tillman is a man who can count all his friends on the fingers of one hand and whose lifelong difficulty with social rituals has convinced him that he is not wired for romance. When an acquaintance suggests that he would make a "wonderful" husband, Don is initially shocked. Despite his skepticism, he cannot deny the statistical probability that there is someone for everyone, leading him to embark upon The Wife Project.

In a methodical, evidence-based manner, Don seeks to find the perfect partner. She will be punctual and logical—most definitely not a barmaid, a smoker, a drinker, or a late-arriver. Yet he meets Rosie Jarman, who embodies all these disqualifying traits. Rosie is also beguiling, fiery, intelligent, and on a quest of her own to identify her biological father. As they collaborate on The Father Project, Don's Wife Project takes a back seat, and an unlikely relationship develops, challenging the genetically minded professor to confront the spontaneous whirlwind that is Rosie—and the realization that love is not always what looks good on paper.

The Rosie Project is a moving and hilarious novel that captures the heart of anyone who has ever tenaciously pursued life or love in the face of overwhelming challenges.