Zoey Redbird's life takes a sharp turn when she is Marked by a Vampire Tracker and enters the House of Night, a school where she will train to become an adult vampyre. Unlike her peers, Zoey has been chosen as special by the vampyre Goddess Nyx, and she possesses affinities for all five elements: Air, Fire, Water, Earth, and Spirit.

As Zoey strives to navigate her new life, she uncovers that she's not the only one with unique powers. The leader of the Dark Daughters, the school's prestigious club, is misusing her abilities. Zoey must summon the courage to confront this challenge and embrace her destiny, with a little support from her new vampyre friends—or as Aphrodite dubs them, the Nerd Herd.