William Sharpe may refer to: William Sharpe (burgess), served in the Virginia House of Burgesses, 1629 William Sharpe (governor) (fl. 1710), governor of Barbados William Sharpe (North Carolina politician) (1742–1818), delegate to the Continental Congress from North Carolina William Sharpe (MP) (1834–1909), British politician William Henry Sharpe (1868–1942), merchant and political figure in Manitoba, Canada William Percy Sharpe (1871–1942), American Democratic politician serving as mayor of Nashville William Sharpe (surgeon) (c. 1882-1960), a brain surgeon who developed treatment for retardation and palsy in children William Sharpe (Alberta politician) (1887–1964), provincial politician from Alberta, Canada William Sharpe (footballer) (fl. 1890), English footballer William C. Sharpe, American cultural historian William R. Sharpe Jr. (1928–2009), member of the West Virginia Senate William F. Sharpe (born 1934), Nobel Prize-winning economist William Frederick Nelson Sharpe Canadian aviation pioneer who died during WWI on Feb 4 1915