This novel is about a woman called Martha. She knows there is something wrong with her but she doesn't know what it is. Her husband Patrick thinks she is fine. He says everyone has something, the thing is just to keep going.

Martha told Patrick before they got married that she didn't want to have children. He said he didn't mind either way because he has loved her since he was fourteen and making her happy is all that matters, although he does not seem able to do it.

By the time Martha finds out what is wrong, it doesn't really matter anymore. It is too late to get the only thing she has ever wanted. Or maybe it will turn out that you can stop loving someone and start again from nothing - if you can find something else to want.

A novel about faith, science, religion, and family that tells the deeply moving portrait of a family of Ghanaian immigrants ravaged by depression and addiction and grief.

Gifty is a fifth-year candidate in neuroscience at Stanford School of Medicine studying reward-seeking behavior in mice and the neural circuits of depression and addiction. Her brother, Nana, was a gifted high school athlete who died of a heroin overdose after a knee injury left him hooked on OxyContin. Her suicidal mother is living in her bed. Gifty is determined to discover the scientific basis for the suffering she sees all around her. But even as she turns to the hard sciences to unlock the mystery of her family's loss, she finds herself hungering for her childhood faith and grappling with the evangelical church in which she was raised, whose promise of salvation remains as tantalizing as it is elusive.