After a research facility is destroyed, the surrounding forest becomes a horrific war zone between intelligent winged mutants and mercenaries hired by the man that created them. When a mutant infects a local, Sarah's cancer is cured and both sides discover that she holds the key to their future.

Sarah Douglas is attacked and infected with the blood of a gargoyle-like creature. The cancer that riddled her body vanishes. The attack draws the attention of Doctor Scott, the scientist who inadvertently was responsible for infecting a colony of bats, changing them into intelligent creatures that could threaten mankind. As the infected blood slowly transforms Sarah's body, she is caught in the middle of a horrific war between an army of mercenaries and a colony of mutated winged creatures.

Watching the creatures gorge themselves on human flesh, she sees her future and fights to maintain her humanity. With Sarah's blood holding the key to his research, the doctor uses his vast resources to try to capture her, while keeping the outside world at bay. This becomes increasingly difficult as the colony expands its territory further away from the Devil's Claw, and members of the local population begin to disappear.