Welcome to Nightshade, California—a small town full of secrets. It’s home to the psychic Giordano sisters, who have a way of getting mixed up in mysteries. During their investigations, they run across everything from pom-pom-shaking vampires to shape-shifting boyfriends to a clue-spewing jukebox. With their psychic powers and some sisterly support, they can crack any case!

Teenage girls are being mysteriously attacked all over town, including at Nightshade High School, where Daisy Giordano is a junior. When Daisy discovers that a vampire may be the culprit, she can’t help but suspect head cheerleader Samantha Devereaux, who returned from summer break with a new “look.” Samantha appears a little... well, dead, and all the most popular kids at school are copying her style. Is looking dead just another fashion trend for Samantha, or is there something more sinister going on? To find out, Daisy joins the cheerleading squad.