Vlad Taltos is a sorcerer and freelance assassin, living as an Easterner (a human) among the Dragaerans. He has a reptilian familiar with a biting sense of humor. Vlad finds himself in trouble when he must prevent a war that could lead to the destruction of his best friends and the great families of Dragaera.

The first published book, Jhereg is actually the fourth novel in the VLAD TALTOS series timeline. The books recount the adventures of the wisecracking hired killer Vlad, a human on a planet mainly inhabited by the long-lived, extremely tall sorcerers known as the Dragaerans.

One of the most powerful bosses in the Jhereg—Dragaera's premier criminal organization—hires Vlad, one of their guild members, to assassinate Mellar, who stole millions from the Jhereg leadership and fled. Unfortunately, this thief turns out to be protected in a way that makes it difficult for Vlad to do his job without gaining the permanent enmity of a friend.

The reader also learns more about Vlad's past in this, and in other, lives.