A catastrophic, unexplainable plane crash leaves three hundred and thirty dead--no survivors. Among the victims are the wife and two daughters of Joe Carpenter, a Los Angeles Post crime reporter. A year after the crash, still gripped by an almost paralyzing grief, Joe encounters a woman named Rose, who claims to have survived the crash. She holds out the possibility of a secret that will bring Joe peace of mind. But before he can ask any questions, she slips away.

Driven now by rage and a hope almost as unbearable as his grief, Joe sets out to find the mysterious woman. His search immediately leads him into the path of a powerful and shadowy organization hell-bent on stopping Rose before she can reveal what she knows about the crash. Sole Survivor unfolds at a heart-stopping pace, as a desperate chase and a shattering emotional odyssey lead Joe to a truth that will force him to reassess everything he thought he knew about life and death--a truth that, given the chance, will rock the world and redefine the destiny of humanity.