Karen Berger is an influential figure in the world of comic books, renowned for her work as an editor. Her career is most notably marked by her pivotal role in establishing the Vertigo imprint for DC Comics in 1993, where she served as Executive Editor until 2013. Berger's vision and leadership helped shape Vertigo into a celebrated line featuring complex, mature, and unconventional storytelling that pushed the boundaries of mainstream comics.

Throughout her illustrious career, Berger has been recognized with multiple accolades, including the prestigious Eisner Award for "Best Editor" in 1992, 1994, and 1995, highlighting her exceptional contribution to the industry. In her ongoing commitment to the comic book medium, she currently helms Berger Books, an imprint of creator-owned comics published by Dark Horse Comics.